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In Fig. 5, the APC mutations in samples from polyps also match the pks+ signature. In polyp G, we detected a T to C mutations in ATT context on APC gene As well as in polyp File, You will find there's limited T-del in T-homopolymer. It indicates that pks+ may be a prospect course of action answerable for mutations in cancer driver genes With this most cancers individual.
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Along with the single base signature discussed to this point, it is understood that colibactin from pks+ E.coli also induces limited deletions at T homopolymers9,13. We investigated no matter whether brief T deletions at T homopolymers happened in each regular and cancer crypts of our dataset. The small T-del signature was much more apparent than the single base pks+ signature (SPS7/SBS88) and will be present in nearly all samples (Fig.
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